person in maze of hallways “Can’t you just try to do something?”  “It isn’t going to help just to sit there.”  Too often words intended to support turn into poisonous darts.  If we are paralyzed in our depression, don’t these thoughts already go through our mind.  Thanks for stating the obvious, and thanks for reinforcing my self-deprecating thoughts.  Guilt and negativity are potent symptoms of depression.  It seems in the midst of dysfunctional neurophysiology we retain self-awareness of the impairment.  We end up turning on ourselves. The physiology of the disease drives behavioral changes.  Withdrawal and isolation become normative behaviors.  This does not seem to be the case in any other physical illness.  Impaired by infection, heart disease, thyroid problems or other similar ailments, we rarely chastise ourselves for the disability they cause.  Why, then, with depression?

Depression is really a syndrome of multiple pathways leading to the manifestation of depressed mood.  Guilt feelings are an oddly reinforcing part of this.  It’s the fine line between pleasure and pain.  Guilt and negativity feed reward systems in the brain in similar ways positive reinforcement does.  As positive reinforcing systems are impaired, the negative takes its place.  It is often the toxicity of this which leads to thoughts of death and suicide.  Physiology and behavior still have an impact here.

The pathway of physiology driving behavior can also function in the opposite direction.  This is where behavioral activation and the statements at the beginning of this piece do carry some truth.  Behavioral activation involves healthy behaviors like walking, social engagement, even brushing teeth and making the bed.  The brain responds to the environment.  The neurophysiology of depression can respond to behavioral changes. During depression, the positive reinforcing systems are still there, only blunted and impaired.  Pleasurable activities, human contact, and positive thoughts can have restorative functions in brain chemistry and wiring.  This isn’t always enough, and we intervene with medications to affect that physiology.  We may also intervene with somatic treatments like transcranial magnetic stimulation (TMS).  TMS targets the electrical nature of the neurons directly.

Depression is toxic and self-reinforcing.  Those cycles become deeply entrenched.  Negative thoughts are common and reinforce pleasure centers in the brain.  Confronting this with behavioral activation can be difficult, but it is an important part of the puzzle.  Medications may be valuable to help drive physiology in healthy directions.  When these options aren’t enough, TMS may be a valuable modality to directly impact neurons.  Most critically, there is hope.  Options are there.  It just may take some patience to find the right ones.